Flichy-Fernández AJ, Alegre-Domingo T, González-Lemonnier S, Balaguer-Martínez J, Peñarrocha-Diago MA, Jiménez-Soriano Y, Peñarrocha-Oltra D, Bagan JV. Study of serum CTX in 50 oral surgical patients treated with oral bisphosphonates. Med Oral Patol Oral Cir Bucal. 2012 May 1;17 (3):e367-70.
Objectives: To determine whether there is a relationship between the total BP dose administered and the variations
in serum CTX concentration.
Study design: The study included 50 patients requiring dental implant surgery and treated with oral BPs, seen in
an Oral Surgery and Implantology Unit between January 2007 and June 2009. The patients were divided into two
groups: those in which the medication was not suspended before obtaining the laboratory test sample, and those
patients referred from other dental clinics in which BPs was suspended before reporting to our Unit. The total
drug dosage administered and the total dose per kilogram body weight were evaluated for comparison with serum
CTX. The data obtained were correlated to the osteonecrosis risk table developed by Marx et al. in 2007.
Results: There were no significant differences between the two groups in relation to the total administered dose
and the dose in mg/kg b.w. Likewise, in both groups no relationship was observed between the serum CTX value
and the total administered dose or the dose in mg/kg b.w. No differences were found between the two patient
groups regarding chemical osteonecrosis risk based on the criteria of Marx et al.