Bagán JV, Vera F, Milián MA, Peñarrocha M, Peydro A. Verrucous Carcinoma of the Oral Cavity. Rev Stomatol Chir Maxilofac 1988;89:92-6.
The term verrucous carcinoma was coined by Ackerman in 1948 to describe 31 cases of a specific malignant tumor of the oral cavity with peculiar macro/microscopic characteristics, and a generally excellent clinical course following adequate treatment.
Since then, this tumor has been described in other locations, such as esophagus, rectal mucosa, penis, female genital tract, larynx, nasal fossa, pyriform sinus and skin. At present it is accepted as a specific clinicopathological entity with a low degree of malignancy that must be distinguished from conventional squamous cell carcinoma.
This study presents a verrucous carcinoma of the lower gingival mucosa in a male aged 81. Following surgery and 6 000 R radiotherapy, the clinical course was not favorable, possibly as a consequence of incomplete resection. The morphological, optical and ultrastructural characteristics of the tumor tissue obtained prior to radiotherapy are described.